1

labarai

Abun ciki

Melanoma yana da kashi 4% kawai na duk cututtukan fata amma yana daga cikin cututtukan cututtukan fata masu saurin kisa. Dacarbazine shine zabi na magani don maganin melanoma a cikin Brazil ta hanyar tsarin kiwon lafiyar jama'a galibi saboda ƙarancin farashi. Koyaya, yana wakiltar alkylating wakili na ƙananan takamaiman bayani kuma yana haifar da amsawar warkewa cikin kawai 20% na shari'o'in. Sauran magungunan da ake dasu don maganin melanoma suna da tsada, kuma ƙwayoyin tumo suna haifar da juriya ga waɗannan magungunan. Yaki da melanoma yana buƙatar sabon abu, takamaiman takamaiman magunguna waɗanda ke da tasiri wajen kashe ƙwayoyin ƙwayoyin cuta masu juriya. Dibenzoylmethane (1,3-diphenylpropane-1,3-dione) abubuwanda suka samo asali sune masu ba da kariya ga wakilan antitumor. A cikin wannan binciken, mun binciki tasirin cytotoxic na 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) akan kwayoyin melanoma na B16F10 da kuma yadda yake hulɗa kai tsaye tare da kwayar DNA ta amfani da hanzarin gani. DPBP ya nuna sakamako mai gamsarwa game da ƙwayoyin tumo kuma yana da zaɓi na zaɓi na 41.94. Hakanan, mun nuna ikon DPBP don yin ma'amala kai tsaye tare da jigidar DNA. Gaskiyar cewa DPBP na iya yin hulɗa tare da DNA a cikin vitro yana ba mu damar ɗauka cewa irin wannan hulɗar na iya faruwa a cikin rayuwa kuma, sabili da haka, cewa DPBP na iya zama madadin kula da marasa lafiya da melanomas mai tsayayya da ƙwayoyi. Wadannan binciken zasu iya jagorantar ci gaban sabbin magunguna masu inganci.

Zane mai zane

3

Makirci na yawan mutuwar kwayar halitta da aka samo don haɗin DPBP akan layin melan-A da B16F10 a cikin ɗumbin yanayi. Icesididdigar zaɓin (SI = IC50 melan-A / IC50 B16F10) ya kasance 41.94.                    

An buga ta Elsevier BV

Abun ciki

Dibenzoylmethane (DBM) ƙaramin yanki ne na licorice kuma logue-diketone analog na curcumin. Ciyar da 1% DBM a cikin abincin ga berayen Sencar a lokacin farawa da lokacin ƙaddamarwa da ƙarfi ya hana 7,12-dimethylbenz [a] anthracene (DMBA) -daɗaɗɗen ƙwayar mammary da yawa da ƙwayar mammary da ke faruwa ta hanyar 97%. Bugu da ƙari a cikin nazarin nazarin rayuwa don bayyana hanyoyin da za a iya hana aikin hana na DBM, ciyar da 1% DBM a cikin abincin AIN-76A ga ƙananan berayen Sencar na makonni 4-5 sun rage nauyin rigar mahaifa ta 43%, ya hana yawan ƙaruwa na kwayoyin halittar mammary gland epithelial da 53%, epithelium na mahaifa da kashi 23%, da kuma bugun mahaifa da kashi 77%, lokacin da aka kashe beraye a lokacin farkon yanayin estrus. Bugu da kari, ciyar da 1% DBM a cikin abinci ga berayen Sencar a makwanni 2 kafin, a lokacin da mako 1 bayan maganin DMBA (intubation na 1 MG DMBA a kowane linzami sau ɗaya a mako na mako 5) ya hana samuwar jimlar DMBA – DNA ta ɗauka a cikin mammary gland ta hanyar 72% ta amfani da gwajin lakabin-post-32P. Don haka, ciyar da abincin 1% DBM ga beran Sencar ya hana samuwar DMBA-DNA a cikin glandon mammary kuma ya saukar da yawan yaduwar mammary gland a vivo. Wadannan sakamakon na iya bayyana karfin ayyukan hanawa na DBM na abinci akan mama na sankara a jikin beraye.


Post lokaci: Aug-12-2020